Coartem (artemether/lumefantrine) is indicated for the treatment of uncomplicated malaria due to Plasmodium falciparum; it is contraindicated in patients with a known hypersensitivity to artemether, lumefantrine, or any component of the formulation; common side effects may include headache, dizziness, and gastrointestinal disturbances; and it may interact with drugs that affect the metabolism of cytochrome P450 enzymes, potentially altering the effectiveness or increasing toxicity of either medication.